Nabota® Botulinum Toxin Type A (100 Units) is a South Korean–manufactured muscle relaxant formulated from Clostridium botulinum neurotoxin. It targets areas of excessive muscle tone or dynamic facial expression to temporarily reduce lines and wrinkles.
Key Benefits
- Smoothes dynamic wrinkles for a rejuvenated appearance
- Reduces excessive sweating in underarms, palms, and soles
- Delivers aesthetic effects lasting 6–9 months
- Provides therapeutic relief for chronic migraines and involuntary muscle spasms
Features & Specifications
- Active Ingredient: Botulinum toxin type A (100 Units per vial)
- Diluent: 0.9% Sodium Chloride
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Dilution Guide (per 0.1 mL):
- 1.0 mL → 10 U
- 2.0 mL → 5 U
- 2.5 mL → 4 U
- 4.0 mL → 2.5 U
- 8.0 mL → 1.25 U
- Package: 1 vial (100 Units)
- Needle: 30 gauge recommended
- Aesthetic Duration: 6–9 months
- Shelf Life: 36 months from the manufacture date
Storage
Store at 2~8℃.
Usage & Administration
Cosmetic Indications
- Forehead lines, glabellar (frown) lines, crow’s feet
- Nasolabial folds, perioral wrinkles, brow wrinkles
Therapeutic Indications
- Chronic migraine prophylaxis (head and neck injection sites)
- Hyperhidrosis (underarms, palms, soles)
- Muscle spasm disorders (e.g., cervical dystonia, blepharospasm)
Dosage Guidelines
- Cosmetic sessions typically use 20–60 Units, adjusted per treatment area
- Higher doses may be needed for therapeutic applications
- Administer only by qualified healthcare professionals
Mechanism of Action
Nabota® binds to presynaptic nerve terminals and blocks acetylcholine release at the neuromuscular junction, preventing muscle contraction and reducing local muscle activity or sweat secretion.
Safety & Contraindications
Common Side Effects: Localized injection-site pain, bruising, headache, and temporary adjacent muscle weakness
Rare Reactions: Allergic responses
Precautions
- Review patient history for neuromuscular disorders or hypersensitivity
- Use with caution in patients with impaired respiratory function
Injection Interval: 2–3 treatment sessions per year, as clinically indicated
Call to Action
Experience smoother lines and targeted relief with professional Nabota® treatments. Contact your certified provider to schedule a consultation and tailor a treatment plan to your needs.
Shipping & Origin
- Manufactured in: Korea
- Shipping: Available globally for international distribution
NABOTA® is a high-purity Botulinum Toxin Type A formulation developed by Daewoong Pharmaceuticals. FDA-approved and backed by multiple clinical trials, it delivers reliable, temporary smoothing of moderate to severe dynamic wrinkles.
Composition
- Clostridium botulinum toxin type A: 200 U
- Human serum albumin: 0.5 mg
- Sodium chloride: 0.9 mg
Appearance & Reconstitution
Supplied as a white-to-light-yellow lyophilisate in a clear vial. Reconstitute with sterile, preservative-free 0.9 % saline to achieve 4 U/0.1 mL (200 U/5 mL). Gently swirl; avoid agitation—label with date/time and use within 24 hours.
Mechanism of Action
NABOTA® inhibits acetylcholine release at neuromuscular junctions, producing localized muscle relaxation that softens expression lines and relieves hyperactive muscle conditions.
Indications
Aesthetic
- Temporary improvement of moderate to severe glabellar lines
- Forehead lines
- Crow’s feet
- Periorbital and perioral wrinkles
Therapeutic
- Chronic migraine prevention
- Neurogenic detrusor overactivity (urinary incontinence)
- Axillary hyperhidrosis
Administration
Inject intramuscularly using a 30–33 G needle. Tailor dose and injection sites to individual anatomy and treatment goals. Typical interval between treatments is 3–6 months.
Storage & Shelf Life
Store unopened vials at 2–8 °C; do not freeze. Maintain aseptic handling of the reconstituted product. Shelf life: 36 months from manufacture.
Safety & Precautions
Administer only by licensed professionals. Inspect the solution for particulate matter and discoloration before use. Contraindicated in patients with known hypersensitivity to any component. Common adverse events include injection-site discomfort, localized weakness, and transient ptosis. Serious systemic effects are rare but warrant prompt medical attention.
Disclaimer:
Bruno Dermal Fillerth products are strictly intended for use by licensed medical and aesthetic professionals. Not suitable for self-administration or use by untrained individuals.
